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KMID : 0379520060220040453
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한국독성학회지
2006 Volume.22 No. 4 p.453 ~ p.458
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Acute Oral Toxicity of Surfactin C in Mice
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Park Byung-Kwon
Lim Jong-Hwan
Hwang Youn-Hwan
Kim Myoung-Seok
Song In-Bae
Lee Hong-Gee
Han Sung-Jin
Hwang Mi-Hyun
Kim Jong-Woo
Rhee Man-Hee
Park Seung-Chun
Yun Hyo-In
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Abstract
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This study was carried out to investigate the acute toxicity of surfactin C in mice. Surfactin C was administered orally at does of 0, 381, 610, 977, 1562 and 2500 mg/kg. Number of deaths, clinical signs, body weights, feed and water consumptions, and biochemical examinations were investigated for 14 days after single oral administration of surfactin C. LD_{50} value was over 2500mg/kg in mice. In addition, no differences were found between control and treated groups in clinical signs, body weight gains, hematology, serum chemistry, feed and water consumptions. The results indicate that surfactin C did not show any toxic effects at 2500 mg/kg in mice.
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KEYWORD
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Acute oral toxicity, Surfactin, LD_{50}, Mouse
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